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>> you feel fantastic. >> you feel fantastic is what people will report, that's correct. >> okay. that's the first time. you use heroin. then what happens? >> well, because dopamine levels continue to increase as a consequence of heroin use reception number goes down, what that means in the real world is you need to use more drugs to get the same high. so what you hear is people are chasing that first high, and to do so, you need to increase your dose. >> and then, eventually, through time, you cook your brain. >> you lose dopamine receptors, throughout time, i think one of the things we need ...