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Antibodies produced from infection with SARS-CoV-2 501Y.V2 protect against other variants

Antibodies produced from infection with SARS-CoV-2 501Y.V2 protect against other variants
As the coronavirus disease 2019 (COVID-19) pandemic continues to claim thousands of lives daily around the world, the pathogen responsible for it, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to undergo mutational changes. A recent paper in the journal
Nature shows that while earlier lineages do not elicit antibodies capable of efficiently neutralizing the newly emerged South African variant, SARS-CoV-2 501Y.V2 (B.1.351), the converse does occur.
The SARS-CoV-2 501Y.V2 variant
The constant occurrence of mutations in the various regions of the viral genome has led to the emergence of a multitude of variants, some of which have become global variants of concern (VOCs). ....

South Africa , South African , Oxford Astrazeneca , Liji Thomas , Alexander Limbach , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Convalescent Plasma , Corona Virus , Coronavirus Disease Covid 19 , Genomic Sequencing , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , அலெக்சாண்டர் லிம்பாக் , சுறுசுறுப்பான பிளாஸ்மா , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Study estimates impact of amino acid changes on SARS-CoV-2 infection

Study estimates impact of amino acid changes on SARS-CoV-2 infection
New research led by Costas D. Maranas from The Pennsylvania State University predicts amino acid changes to the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein would negatively impact binding affinity and subsequent infection into human cells.
Their results were derived from a novel two-step procedure called neural network molecular mechanics/Poisson-Boltzmann surface area (NN MM-GBSA) that calculated binding energy from receptor-binding domain variants to human angiotensin-converting enzyme 2 (ACE2) receptors. The second step would construct a neural network from the findings to predict binding affinity. The team achieved an 82.2% accuracy rate for categorizing amino acid substitutions as helpful or unhelpful in a variant s binding affinity. ....

South Africa , South African , Costasd Maranas , Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , Pennsylvania State University , Amino Acid , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , பென்சில்வேனியா நிலை பல்கலைக்கழகம் , அமினோ அமிலம் , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Mice study points to a promising treatment for relieving colitis pain without side effects

Mice study points to a promising treatment for relieving colitis pain without side effects
A targeted opioid that only treats diseased tissues and spares healthy tissues relieves pain from inflammatory bowel disease without causing side effects, according to new research published in the journal
Gut.
The study, led by researchers at New York University College of Dentistry and Queen s University in Ontario, was conducted in mice with colitis, an inflammatory bowel disease marked by inflammation of the large intestine.
Opioids, which are used to treat chronic pain in people with inflammatory bowel disease, relieve pain by targeting opioid receptors, including the mu opioid receptor. When opioids activate the mu opioid receptor in healthy tissues, however, they can cause severe and life-threatening side effects, including difficulty breathing, constipation, sedation, and addiction. ....

Nigel Bunnett , Christoph Stein , Emily Henderson , College Of Dentistry , York University College Of Dentistry , Queen University In Ontario , Department Of Molecular Pathobiology , New York University College , Molecular Pathobiology , Chronic Pain , Inflammatory Bowel Disease , Large Intestine , நைகல் பன்னெட் , கிறிஸ்டோஃப் ஸ்டீன் , எமிலி ஹென்டர்சன் , கல்லூரி ஆஃப் பல் மருத்துவம் , யார்க் பல்கலைக்கழகம் கல்லூரி ஆஃப் பல் மருத்துவம் , ராணி பல்கலைக்கழகம் இல் ஆஂடேரியொ , புதியது யார்க் பல்கலைக்கழகம் கல்லூரி , நாள்பட்ட வலி , அழற்சி குடல் நோய் , பெரியது குடல் ,

Could a flavonoid found in common fruit and vegetables combat COVID-19?

Researchers in India have gathered and presented a large body of evidence highlight quercetin – a flavonoid molecule found in many common fruits and vegetables – may be developed into drug therapies used to combat COVID-19. ....

Michael Burgess , Michael Burgessapr , Deepu Matthew , Molecular Biology Department , Centre For Plant Biotechnology , Kerala Agricultural University , Beni Suef University Journal , Applied Sciences , Monkey Business Images , Plant Biotechnology , Molecular Biology , Antiviral Drug , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Rheumatoid Arthritis , Spike Protein , மைக்கேல் பர்கஸ் , தீபு மேத்யூ , மூலக்கூறு உயிரியல் துறை , மையம் க்கு ஆலை உயிரி தொழில்நுட்பவியல் , பயன்படுத்தப்பட்டது அறிவியல் , குரங்கு வணிக படங்கள் , ஆலை உயிரி தொழில்நுட்பவியல் , மூலக்கூறு உயிரியல் , கொரோனா வைரஸ் ,

Researchers reveal novel therapeutic target in the treatment of certain cancers

Researchers reveal novel therapeutic target in the treatment of certain cancers
Mount Sinai Researchers Find Removal of AKAP11 Protein by Autophagy as a key to Fuel Mitochondrial Metabolism and Tumor Cell Growth through activating protein kinase A (PKA) (Patent pending)
Corresponding Author: Zhenyu Yue, PhD, Professor of Neurology, Aidekman Family Professorship, Director of Basic and Translational Research in Movement Disorders, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai.
Bottom Line: We uncovered a mechanism that tumor cells exploit selective autophagy for metabolic reprogramming that benefits tumor cell growth and offers resistance to glucose deprivation. Our study suggests that AKAP220-mediated autophagy as a novel therapeutic target for specific cancer treatment. ....

Zhenyu Yue , Emily Henderson , Why The Research Is Interesting , Translational Research In Movement Disorders , Icahn School Of Medicine At Mount Sinai , Friedman Brain Institute , Sinai Researchers Find , Fuel Mitochondrial Metabolism , Tumor Cell Growth , Aidekman Family Professorship , Translational Research , Movement Disorders , Icahn School , Research Is Interesting , Selective Autophagy , Tumor Cell , Mount Sinai , Cancer Treatment , Cell Metabolism , எமிலி ஹென்டர்சன் , ஏன் தி ஆராய்ச்சி இருக்கிறது சுவாரஸ்யமானது , மொழிபெயர்ப்பு ஆராய்ச்சி இல் இயக்கம் கோளாறுகள் , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ஏற்ற சினை , ப்ரைட்மேன் மூளை நிறுவனம் , சினை ஆராய்ச்சியாளர்கள் கண்டுபிடி , எரிபொருள் மைட்டோகாண்ட்ரியல் வளர்சிதை மாற்றம் ,