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Wednesday, December 16, 2020 On November 9, 2020, EPA’s Office of Research and Development (ORD) released its long-awaited draft handbook that details the office’s process for developing chemical hazard assessments for its Integrated Risk Information System (IRIS) Program. The ORD Staff Handbook for Developing IRIS Assessments (IRIS Handbook) gives useful insight into ORD’s process to develop its IRIS assessments, which provide important toxicological information that federal and state environmental agencies consider when making regulatory and cleanup decisions under multiple statutory programs. EPA will accept comments on the draft handbook and charge questions until March 1, 2021. Background EPA established the IRIS Program in 1985, with the goal of creating a database of human health assessments for chemicals found in the environment to ensure that evaluation of chemical toxicity was consistent across the Agency. Today, EPA’s public IRIS website ....