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Tiny fragment of brain tissue. it was too small for rflp testing since it was about the size of a pinhead. so scientists amplified it, using pcr, a process that duplicates a small sample to make it large enough to test. the pcr dna tests revealed that the brain tissue in larry moore's camper was brad brisbin's. >> i knew it was going to be a match. the official confirmation that the blood matched was huge. i never felt anything like that before. >> with this discovery, the medical examiner ruled brad brisbin's death a homicide. larry moore was arrested and charged with murder. but prosecutors ...

>> we can help you to determine whether this tissue is from the missing person by comparing the dna from the tissue to the family members and the children and the mother of the person who is missing. >> children get half of their dna from the mother and half from the father. by taking a dna sample from brad's wife, his four children and his mother, scientists could isolate brad's dna profile through a process of elimination. for this, scientists used an rflp test. at the time the most sophisticated dna test available. >> whose ever tissue sample that was was completely consistent with being th...

>> next, scientists tested the tiny fragment of brain tissue. it was too small for rflp testing since it was about the size of a pinhead. so scientists amplified it, using pcr, a process that duplicates a small sample to make it large enough to test. the pcr dna tests revealed that the brain tissue in larry moore's camper was brad brisbin's. >> i knew it was going to be a match. this confirmation that the blood matched was huge. i never felt anything like that before. >> with this discovery, the medical examiner ruled brad brisbin's death a homicide. larry moore was arrested and charged with m...

>> next, scientists tested the tiny fragment of brain tissue. it was too small for rflp testing since it was about the size of a pinhead. so scientists amplified it, using pcr, a process that duplicates a small sample to make it large enough to test. the pcr dna tests revealed that the brain tissue in larry moore's camper was brad brisbin's. >> i knew it was going to be a match. this confirmation that the blood matched was huge. i never felt anything like that before. >> with this discovery, the medical examiner ruled brad brisbin's death a homicide. larry moore was arrested and charged with m...

>> next, scientists tested the tiny fragment of brain tissue. it was too small for rflp testing since it was about the size of a pinhead. so scientists amplified it, using pcr, a process that duplicates a small sample to make it large enough to test. the pcr dna tests revealed that the brain tissue in larry moore's camper was brad brisbin's. >> i knew it was going to be a match. this confirmation that the blood matched was huge. i never felt anything like that before. >> with this discovery, the medical examiner ruled brad brisbin's death a homicide. larry moore was arrested and charged with m...