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"Towards Building a Quantitative Proteomics Toolbox in Precision Medici" by Alejandro Correa Rojo, Dries Heylen et al.

Precision medicine as a framework for disease diagnosis, treatment, and prevention at the molecular level has entered clinical practice. From the start, genetics has been an indispensable tool to understand and stratify the biology of chronic and complex diseases in precision medicine. However, with the advances in biomedical and omics technologies, quantitative proteomics is emerging as a powerful technology complementing genetics. Quantitative proteomics provide insight about the dynamic behaviour of proteins as they represent intermediate phenotypes. They provide direct biological insights into physiological patterns, while genetics accounting for baseline characteristics. Additionally, it opens a wide range of applications in clinical diagnostics, treatment stratification, and drug discovery. In this mini-review, we discuss the current status of quantitative proteomics in precision medicine including the available technologies and common methods to analyze quantitative proteomics d ....

Biomarker Discovery , Clinical Diagnostics , Precision Medicine , Rotein Quantitative Trait Loci , Quantitative Proteomics , Argeted Techniques ,