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Sarcopenia and Sarcopenic Obesity and Mortality Among Older People 1. In this secondary analysis of the Rotterdam study, older adults with sarcopenia and sarcopenic obesity (SO) were at significantly higher risk for all-cause mortality than their non-SO counterparts. Evidence Rating Level: 2 (Good) Sarcopenia, or low skeletal muscle mass and strength, is a phenotype of
Researchers used a UHPLC and mass spectrometry-based Metabolon platform to identify and characterize circulating metabolites associated with depression.
An analysis of 2 population-based cohorts suggests coronary artery calcium scores added to traditional risk-based models showed better discrimination than polygenic risk scores for CHD risk prediction.
Data show CV risk discrimination improved when adding a coronary artery calcium score to a CHD prediction model based on traditional risk factors; however, there were no changes when adding a polygenic risk score.The analysis of two large cohorts of middle-age and older adults with long-term follow-up — all with available genetic data and coronary CT scans — addresses a key knowledge
The combination of the two scores also had no additive predictive power compared with the coronary artery calcium score alone, the researchers found.