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The new sequence establishes a whole host of characters within the village, including Jason Donovan's daughter Jemma, 22, who plays Rayne Royce.
Two TV stars have been spotted alongside a camera crew on Brighton Beach.
In upcoming scenes, the devastated teen will head to the coast with her on-off girlfriend for the emotional outing, as her family fear whether she will survive her battle with the disease.
She was recently diagnosed with lymphoma, and some new test results force her to talk seriously about her future with Peri, after ending her relationship with Nadira Valli.
It looks as though 2023 is set to be even more dramatic, with Hollyoaks bosses lining up some nail-biting plots that will keep viewers hooked in the coming months.