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GPCR-targeting drugs make up around a third of those approved by the FDA, yet often come with side effects. New research into the mechanisms of GPCR activation could help design drugs to prevent side effects.
New imaging technique captures movies of receptors on the surface of living cells A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children's Research Hospital captures movies of receptors on the surface of living cells in unprecedented detail and could pave the way to a trove of new drugs. The researchers used the technique to zoom in on individual receptor proteins on the surface of living cells to determine if the receptors work solo or come together to work as pairs. This work appeared in the April issue of Nat...
E-Mail NEW YORK, NY--A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children's Research Hospital captures movies of receptors on the surface of living cells in unprecedented detail and could pave the way to a trove of new drugs. The researchers used the technique to zoom in on individual receptor proteins on the surface of living cells to determine if the receptors work solo or come together to work as pairs. This work appeared in the April issue of Nature Methods. "If two different receptors come together t...
Columbia University Irving Medical Center A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children’s Research Hospital captures movies of receptors on the surface of living cells in unprecedented detail and could pave the way to a trove of new drugs. The researchers used the technique to zoom in on individual receptor proteins on the surface of living cells to determine if the receptors work solo or come together to work as pairs. This work appeared in the April issue of Nature Methods. “If two different recept...