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Study reveals role of neutrophil lipid transfer in lung cancer transition

Phenotypic plasticity is a cancer hallmark, and lung adeno-to-squamous transition (AST) triggered by LKB1 inactivation is significantly associated with drug resistance. Clinical data show that squamous transition occurs in certain lung adenocarcinoma patients who relapse from targeted therapy using EGFR tyrosine-kinase inhibitors (TKIs) or KRAS inhibitor. However, the epigenetic regulatory mechanisms involved in AST remain largely unknown. ....

Ji Hongbin , Yun Xue , Shanghai Institute Of Biochemistry , Shanghai Medical College Of Fudan University , Experimental Medicine , Molecular Cell Science , Shanghai Institute , Cell Biology , Chinese Academy , Shanghai Medical College , Fudan University ,

Study sheds light on how androgens shape sex differences at the cellular and molecular levels

Sex differences are widespread across human development, physiological processes, and diseases, making it important to characterize the impact of sex differences in these areas. ....

Shanghai Institute Of Biochemistry , Chinese Academy Of Sciences , Shenzhen Bay Laboratory , Chinese Academy Of Sciences Headquarters , Molecular Cell Science , Shanghai Institute , Cell Biology , Chinese Academy , Peking University , United Kingdom Biobank ,

Sex-Biased Disease Targets Found in Single-Cell and UK Biobank Data Merge

Sex-Biased Disease Targets Found in Single-Cell and UK Biobank Data Merge
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Institute Of Cancer Research , Shanghai Institute Of Biochemistry , Shenzhen Bay Laboratory , Shanghai Institute , Cell Biology , Chinese Academy , Cancer Research , United Kingdom Biobank ,

Scientists Probe Androgens' Impact on Sex Differences

Scientists Probe Androgens' Impact on Sex Differences
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Shenzhen Bay Laboratory , Shanghai Institute Of Biochemistry , Molecular Cell Science , Shanghai Institute , Cell Biology , Chinese Academy , Peking University , United Kingdom Biobank ,

Researchers explore role of androgens in shaping sex differences

Researchers explore role of androgens in shaping sex differences
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Yu Chen , Gao Dong , Chen Luonan , Shenzhen Bay Laboratory , Shanghai Institute Of Biochemistry , Molecular Cell Science , Shanghai Institute , Cell Biology , Chinese Academy , Bai Fan , Peking University , United Kingdom Biobank ,