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Study finds molecular pathway that can explain how chronic kidney disease induces heart failure - Vimarsana News

Study finds molecular pathway that can explain how chronic kidney disease induces heart failure

According to the Global Burden of Disease Study 2017, close to nine percent of the global population lives with some form of chronic kidney disease, or CKD. Not only does the condition affect renal function, CKD has long been associated with increased risk of cardiovascular disease.

How do bad kidneys lead to heart disease? Broken cellular clocks provide new clues - Vimarsana News

How do bad kidneys lead to heart disease? Broken cellular clocks provide new clues

Kyushu University researchers find that one of the causes of CKD induced heart failures is the over expression of G protein-coupled receptor 68 in monocytes. Monocyte disruption was caused by the activation of the Clock gene, the key regulator of circadian rhythm via the increased level of vitamin A in the body resulting from kidney dysfunction.