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Date Time Researchers find clues to sex differences in autism It is well established that autism occurs much more frequently in boys than in girls, and that girls seem to have a greater resilience to developing the condition. It has been unclear, however, why that is. In a new Yale-led study, researchers find that autism may develop in different regions of the brain in girls than boys and that girls with autism have a larger number of genetic mutations than boys, suggesting that they require a larger “genetic hit” to develop the disorder. “We know so little about how autism unfolds in t...

Studies Indicate How Mosaic Mutations Contribute to Autism Risk January 13, 2021 Two studies published in Nature Neuroscience implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The investigations, led by researchers at Boston Children’s Hospital, Brigham and Women’s Hospital (BWH), and Harvard Medical School (HMS), point to new areas for exploring the genetics of ASD and could eventually inform diagnostic testing. The two reported studies were part of the Brain Somatic Mosaicism Network, funded by the National Institute of Menta...

Two studies in today's Nature Neuroscience, led by researchers at Boston Children's Hospital, Brigham and Women's Hospital (BWH), and Harvard Medical School (HMS), implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The findings open new areas for exploring the genetics of ASD and could eventually inform diagnostic testing. Mosaic mutations affect only a portion of a person's cells. Rather than being inherited, they arise as a "mistake" introduced when a stem cell divides. A mutation in a stem cell will only be passed to the cells tha...