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"Hidden Glutathione Transferases in the Human Genome" by Aaron J. Oakley

With the development of accurate protein structure prediction algorithms, artificial intelligence (AI) has emerged as a powerful tool in the field of structural biology. AI-based algorithms have been used to analyze large amounts of protein sequence data including the human proteome, complementing experimental structure data found in resources such as the Protein Data Bank. The EBI AlphaFold Protein Structure Database (for example) contains over 230 million structures. In this study, these data have been analyzed to find all human proteins containing (or predicted to contain) the cytosolic glutathione transferase (cGST) fold. A total of 39 proteins were found, including the alpha-, mu-, pi-, sigma-, zeta- and omega-class GSTs, intracellular chloride channels, metaxins, multisynthetase complex components, elongation factor 1 complex components and others. Three broad themes emerge: cGST domains as enzymes, as chloride ion channels and as protein–protein interaction mediators. As the m ....

Protein Data Bank , Protein Data , Fold Protein Structure Database , Eukaryotic Elongation Factor 1 , Ailed Axon Connections Homolog , Anglioside Induced Differentiation Associated Protein , Lutathiones Transferasec Terminal Domain Containing Protein , Lutathione Transferase , Ntracellular Chloride Channel , Ulti Trna Synthetase Complex , Structure Prediction ,

Eric Schmidt: This is how AI will transform how science gets done

Eric Schmidt: This is how AI will transform how science gets done
technologyreview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from technologyreview.com Daily Mail and Mail on Sunday newspapers.

Andrew White , Minkyung Baek , Deepmind Alphafold , Stuart Russell , Google Deepmind , David Baker , World Health Organization , Emerald Cloud Lab , Argonne National Laboratory , University Of Rochester , University Of Washington , Argonne National , Critical Assessment , Structure Prediction , King Midas ,

Identifying Elusive Post-Translational Modifications

Post-translational modifications (PTMs) provide a rapid mechanism that enables protein phenotypic diversity so that proteins can react to external and internal disturbances and regulate cellular activity. This Biotech Brief discusses tools and methods that are employed in detecting these sub-stoichiometric and elusive protein modifiers, including mass spectrometry, antibody, artificial intelligence, ubiquitin-clipping, and specific uncaging-assisted biotinylation-based approaches. The article also discusses challenges in detecting PTMs, such as the development of PTM antibodies with high specificity and binding affinity. ....

Claire Eyers , Cristina Martin Granados , Nucleic Acids Research , Opin Genet , Structure Database , Acids Research , Understand Protein Structure , Structure Prediction , Mass Spectrometry , Annual Review , Physical Chemistry ,