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Identifying Elusive Post-Translational Modifications

Post-translational modifications (PTMs) provide a rapid mechanism that enables protein phenotypic diversity so that proteins can react to external and internal disturbances and regulate cellular activity. This Biotech Brief discusses tools and methods that are employed in detecting these sub-stoichiometric and elusive protein modifiers, including mass spectrometry, antibody, artificial intelligence, ubiquitin-clipping, and specific uncaging-assisted biotinylation-based approaches. The article also discusses challenges in detecting PTMs, such as the development of PTM antibodies with high specificity and binding affinity. ....

Claire Eyers , Cristina Martin Granados , Nucleic Acids Research , Opin Genet , Structure Database , Acids Research , Understand Protein Structure , Structure Prediction , Mass Spectrometry , Annual Review , Physical Chemistry ,

Bangladeshi student wins prestigious award in computational biology competition

Bangladeshi student wins prestigious award in computational biology competition: Raj Shekhor Roy, a Bangladeshi PhD student under the supervision of Dr. Jianlin Cheng, has garnered exceptional success at the prestigious Critical Assessment of Structure Prediction (CASP) competition in the Estimation of Model Accuracy (EMA) category, making him one of the few Bangladeshis to ....

Jianlin Cheng , Raj Shekhor Roy , Bangladeshi Phd , Critical Assessment , Structure Prediction , Model Accuracy ,

AlphaFold AI Uncovers New 3D Proteins with Open Data

AlphaFold AI Uncovers New 3D Proteins with Open Data
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

City Of , United Kingdom , John Jumper , Sameer Velankar , Janet Thornton , Europe Pdbe , John Kendrew , Protein Data Bank , European Bioinformatics Institute , Alphafold Team , Senior Staff Research Scientist At Deepmind , Team Leader For The Protein Data Bank , World Health Organisation , John Moult , Critical Assessment , Structure Prediction , Senior Staff Research Scientist , Protein Data , Sharing Alphafold , Alphafold Protein Structure Database , Alphafold Database , Structure Database , Fold Nature , Director Emeritus ,

AlphaFold's AI protein-structure predictions have limits

AlphaFold's AI protein-structure predictions have limits
sciencenews.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencenews.org Daily Mail and Mail on Sunday newspapers.

City Of , United Kingdom , Demis Hassabis , Jane Dyson , Tamir Gonen , Julie Forman Kay , Nazim Bouatta , Harvard Medical School Bouatta , David Geffen School Of Medicine , Harvard Medical School , University Of Maryland Rockville , University Of Toronto , Protein Data Bank , Scripps Research Institute In La Jolla , Howard Hughes Medical Institute , James Webb Space Telescope , European Bioinformatics Institute , European Molecular Biology Laboratory , Protein Data , Sick Children , David Geffen School , Harvard Medical , John Moult , Critical Assessment , Structure Prediction , Scripps Research Institute ,

AlphaFold Developers Win $3-Million Breakthrough Prize in Life Sciences

DeepMind’s system for predicting the 3D structure of proteins is among five recipients of science’s most lucrative awards ....

New York , United States , United Kingdom , Columbia University , City Of , Yale University , Soult Ukpyolsi , South Korea , New Jersey , New Haven , David Deutsch , John Jumper , Deepmind Alphago , Demis Hassabis , Birgitte Rahbek Kornum , Nikita Gourianov , Mark Zuckerberg , Gilles Brassard , Peter Shor , Masashi Yanagisawa , Charles Bennett , Daniel Spielman , Christine Orengo , Anthony Hyman , Mohammed Alquraishi , Lee Sedol ,