"Plausibility of Claimed Covid-19 Vaccine Efficacies by Age: A Simulati" by Kyle A. Sheldrick, Gideon Meyerowitz-Katz et al.
Background:Multiple vaccines against Covid-19 have passed through phase-3 trials; however, concerns have been raised about alleged excessive similarity of efficacy across age groups for the Sputnik V vaccine.Study Question:How likely are the observed efficacies for all age subgroups to fall within the range of by-age efficacies claimed for the AstraZeneca, Janssen, Moderna, Pfizer, and Sputnik V vaccines, assuming that there is no effect of age on efficacy?Study Design:We performed a simulation study using R of 1000 and then 50,000 simulated trials for each vaccine, with random allocation to e...