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The U.S. Environmental Protection Agency (EPA) announced on June 6, 2022, that it issued the first in a series of Toxic Substances Control Act (TSCA) test orders to require companies to...
As part of justification for in vivo inhalation toxicity testing, EPA stated that it considered in vitro respiratory toxicity models and found that currently available in vitro respiratory tract cell culture models are only relevant to water-soluble and gaseous substances.