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Computer simulation model identifies key factors for successful transit of sperm in the genital tract

Computer simulation model identifies key factors for successful transit of sperm in the genital tract
A research team at the Humboldt University Berlin and the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) developed an agent-based computer model to simulate the journey of sperm cells through the female genital tract. Key factors for a successful transit could be identified without the use of animal experiments and were published in the scientific journal "PLoS Computational Biology".
During mating in wildlife species, males transfer millions of sperm into the female genital tract. On the way to the egg cell the sperm have to pass through the genital tract. Very few of the sperm cells actually succeed in passing through and reaching the vicinity of the egg cell. Those that do will then be conditioned for fertilisation. Mechanisms underlying sperm selection and, therefore, reproductive success are largely unknown, as their experimental study in the living organism is very difficult for both ethical and practical reasons. A deeper understanding of the factors which favour successful sperm migration and selection in the context of species-specific reproductive systems would be of great fundamental as well as of applied interest, since for threatened wildlife species this will help recognise reproductive problems and optimise assisted reproduction techniques such as artificial insemination.

Berlin , Germany , Jorin-diemer , Edda-klipp , Emily-henderson , Leibniz-institute-for-zoo , Humboldt-university-berlin , Theoretical-biophysics-department , Wildlife-research , Leibniz-institute , Doctoral-student , Theoretical-biophysics

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Berlin , Germany , Jorin-diemer , Edda-klipp , Leibniz-institute-for-zoo , Humboldt-university-berlin , Theoretical-biophysics-department , Wildlife-research , Leibniz-institute , Theoretical-biophysics , பெர்லின் , ஜெர்மனி

Sperm migration in the genital tract: computer simulations identify factors for success

Sperm migration in the genital tract: computer simulations identify factors for success
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Berlin , Germany , Jens-hahn , Jorin-diemer , Hans-christoph-keller , Edda-klipp , Steven-seet , Department-reproduction-biology , Leibniz-institute-for-zoo , Humboldt-university-berlin , Theoretical-biophysics-department , Wildlife-research