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Researchers identify six “words” used by specific immune cells to call up immune defense genes UCLA life scientists have identified six "words" that specific immune cells use to call up immune defense genes -- an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren's syndrome. The research, conducted in mice, is published this week in the peer-reviewed journal Immunity (Cell Press). Cells h...

  In this image from a microscopy video, scientists "listen" to macrophages as they responded to an immune threat. Credit: Brooks Taylor/ UCLA Life Sciences Read Time: UCLA life scientists have identified six "words" that specific immune cells use to call up immune defense genes -- an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren's syndrome. The research, conducted in mice, is publis...

© Brooks Taylor/UCLA In this image from a microscopy video, scientists “listen” to macrophages as they responded to an immune threat. UCLA life scientists have identified six "words" that specific immune cells use to call up immune defense genes — an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren's syndrome. The research, conducted in mice, is published this week in the peer-review...

The advance, researchers say, is like the cellular equivalent of discovering the Rosetta stone and may eventually lead to new treatments for diseases.

Brooks Taylor/UCLA Life Sciences In this image from a microscopy video, scientists “listen” to macrophages as they responded to an immune threat. UCLA life scientists have identified six “words” that specific immune cells use to call up immune defense genes — an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren’s syndrome. The research, conducted in mice, is published this week in...