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Individual neurons mix multiple RNA edits of key synapse protein, study finds

A new study finds complexin is a key protein for regulating neural communication. New research finds neurons stochastically generated up to eight different versions of complexin release, which could vary how they communicate with other cells.

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Research: Individual Neurons Combine Multiple RNA Edits of Synapse Protein

Research: Individual Neurons Combine Multiple RNA Edits of Synapse Protein
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Individual neurons mix multiple RNA edits of key synapse protein, fly study finds

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds
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Individual neurons mix multiple RNA edits of key synapse protein, fly study finds

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds
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Study connects neural gene expression differences to functional distinctions

The Picower Institute for Learning and Memory found that the two closely related neuronal subtypes differed from each other in how they expressed more than 800 genes. By manipulating genes whose expression differed most prominently, the scientists were then able to show how they produced several of the observable differences between the cells.

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Study connects neural gene expression differences to functional distinctions

Study connects neural gene expression differences to functional distinctions
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Study connects neural gene expression differences to functional distinctions

Study connects neural gene expression differences to functional distinctions
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How Differences in Gene Expression Lead to Functionally Different Neurons

Researchers compared a pair of superficially similar motor neurons in fruit flies to examine how their differing use of the same genome produced distinctions in form and function.

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Key Protein Vital for Structural Integrity of Neurons – Without It Axons Break, Synapses Die

Key Protein Vital for Structural Integrity of Neurons – Without It Axons Break, Synapses Die
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Without a key extracellular protein, neuronal axons break and synaptic connections fall apart

MIT researchers found that without the protein perlecan, axonal segments in fruit flies can break apart during development. The synapses that they form end up dying away.

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