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Researchers develop ultra-small nanomedicines to target intractable cancers

Researchers develop ultra-small nanomedicines to target intractable cancers
Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs.
Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-small nanomedicines in the blood circulation.
The ultra-small size allows for high permeability in cancer tissues by slipping through the cracks in tumor vasculatures and stromal tissues.
Clinical trials and preclinical studies using the developed ultra-small nanomedicines are proceeding for cancer therapy.
Published in the website of
Journal of Controlled Release on January 6.
Main body
The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki-City in Japan, Abbreviation: iCONM) recently developed an ultra-small nanomedicines called Unit Polyion Com ....

Kanjiro Miyata , Kazunori Kataoka , Emily Henderson , Department Of Material Engineering , School Of Engineering , University Of Tokyo , Innovation Center , Controlled Release , Director General , Unit Polyion Complex , Material Engineering , Graduate School , Cancer Therapy , Genetic Information , Nucleic Acid , Pancreatic Cancer , எமிலி ஹென்டர்சன் , துறை ஆஃப் பொருள் பொறியியல் , பள்ளி ஆஃப் பொறியியல் , பல்கலைக்கழகம் ஆஃப் டோக்கியோ , கண்டுபிடிப்பு மையம் , கட்டுப்படுத்தப்படுகிறது வெளியீடு , இயக்குனர் ஜநரல் , பொருள் பொறியியல் , பட்டதாரி பள்ளி , புற்றுநோய் சிகிச்சை ,

Ultra-small nanomedicines which stably deliver oligonucleotides to refractory cancers

Loading video.
VIDEO: Nanomedicines consisting of one molecule of oligonucleotide and one or two
molecules of Y-shaped block copolymer(s), of which the size is approximately
18 nm and is in dynamic equilibrium with free Y-shaped.
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Credit: 2021 Innovation Center of NanoMedicine
Summary
Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs.
Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-small nanomedicines in the blood circulation.
The ultra-small size allows for high permeability in cancer tissues by slipping through the cracks in tumor vasculatures and stromal tissues. ....

Kanjiro Miyata , Mami Satake , Kazunori Kataoka , Makoto Shimazaki , King Skyfront , Department Of Material Engineering , Nature Communications , Innovation Network For Smart Health , Innovation Center , Innovation Program , Technology Agency , School Of Engineering , University Of Tokyo , Public Interest Incorporated Foundation , Research Promotion Office Person , Ministry Of Education , Controlled Release , Director General , Unit Polyion Complex , Material Engineering , Graduate School , Kawasaki City , Japan Science , Open Innovation Network , Smart Health , Promotion Office ,