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The S&P 500 declined 0.25% to end the session at 4,090.38 points. The Nasdaq fell 1.07% to 11,996.86 points, while the Dow Jones Industrial Average rose 0.24% to 33,482.72 points.
The tech-heavy index rallied 17%, with chipmaker Nvidia and social-media giant Meta finishing the quarter as its two best-performing stocks.
Shares in Nvidia are up 84% this year to about $268 apiece thanks to increased hype over artificial intelligence technologies.
"They bought a lot of stuff, and then eventually it collapsed, because it doesn't bring anything useful for society," Nvidia's CTO said.
Analysts at Credit Suisse have a price target of $275 on Nvidia, saying its hardware and software give it an edge over rivals in AI.