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Breaking through the mucus barrier

Breaking through the mucus barrier
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Jochen-lennerz , Zilianng-kang , Alison-hayward , Robert-langer , Nina-fitzgerald , Josh-morimoto , Keiko-ishida , Johannes-kuosmanen , Wiam-abdalla-mohammed-madani , Giovanni-traverso , Amro-alshareef , Joshua-jenkins

New capsule tunnels through mucus in the GI tract to deliver large protein drugs

One reason that it's so difficult to deliver large protein drugs orally is that these drugs can't pass through the mucus barrier that lines the digestive tract.

Jochen-lennerz , Zilianng-kang , Alison-hayward , Robert-langer , Nina-fitzgerald , Emily-henderson , Josh-morimoto , Keiko-ishida , Johannes-kuosmanen , Wiam-abdalla-mohammed-madani , Giovanni-traverso , Amro-alshareef

Breaking through the mucus barrier

A new drug capsule developed at MIT can help large proteins such as insulin and small-molecule drugs be absorbed in the digestive tract. The capsule has a robotic cap that spins and tunnels through the mucus barrier when it reaches the small intestine, allowing drugs carried by the capsule to pass into cells lining the intestine.

Jochen-lennerz , Zilianng-kang , Alison-hayward , Robert-langer , Nina-fitzgerald , Josh-morimoto , Keiko-ishida , Johannes-kuosmanen , Wiam-abdalla-mohammed-madani , Giovanni-traverso , Amro-alshareef , Joshua-jenkins