May 12 2021
Due to its versatility and efficiency, including the low environmental impact and reduced volume of solvents required, solid phase extraction (SPE) is the preferred method for sample cleanup and trace enrichment for many analytical laboratories. Large application fields, like contaminant isolation from environmental and food matrices, now depend on modern SPE techniques. Additionally, SPE is also popular in drug extraction workflows from biological fluids in forensic labs and the DMPK disciplines.
Commonly, there are four steps involved in an SPE method: conditioning, loading, washing, and eluting. The intent is to simplify complex sample matrices, purify the analytes of interest, fractionate a complex mixture of active compounds, or concentrate any trace levels of analytes. Different strategies and extraction schemes may apply depending on the exact application of the SPE process. ....