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New data shows that mINDY gene is involved in blood pressure regulation

New data shows that mINDY gene is involved in blood pressure regulation
Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the
Journal of Clinical Investigation (JCI) insight.
Reduced expression of mINDY, which is known to extend the life span in lower organisms and to prevent diet induced obesity, fatty liver, and insulin resistance in mice, has now been shown to lower blood pressure and heart rate in rodents.
The authors provided mechanistic insights for the underlying physiological mechanism based on in vivo data in a genetic knockout model as well as microarray and in vitro studies. ....

Andreas Birkenfeld , Emily Henderson , Diabetes Research , German Center , Clinical Investigation , Blood Pressure , Fatty Liver , Heart Rate , In Vitro , In Vivo , Insulin Resistance , ஆண்ட்ரியாஸ் பிர்கன்பெல்ட் , எமிலி ஹென்டர்சன் , நீரிழிவு நோய் ஆராய்ச்சி , ஜெர்மன் மையம் , மருத்துவ விசாரணை , இரத்தம் ப்ரெஶர் , நீரிழிவு நோய் , கொழுப்பு கல்லீரல் , இதயம் ரேட் , இல் விட்ரோ , இல் விவோ , இன்சுலின் எதிர்ப்பு , உடல் பருமன் ,

The longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation

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Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the
Journal of Clinical Investigation (JCI) insight. Reduced expression of mINDY, which is known to extend life span in lower organisms and to prevent from diet induced obesity, fatty liver and insulin resistance in mice, has now been shown to lower blood pressure and heart rate in rodents. The authors provided mechanistic insights for the underlying physiological mechanism based on in vivo data in a genetic knock out model as well as microarray and in vitro studies. Furthermore, the hypothesis is supported by confirming critical effects in vitro using a small molecule inhibitor of mINDY. The authors conclude that deletion of mIndy recapitulates beneficial cardiovascular and metabolic responses to caloric restriction, making it an attractive therapeutic target. ....

Baden Wuberg , Andreas Birkenfeld , Andreasl Birkenfeld , Department Of Internal Medicine , German Diabetes Center , German Research Center , Environmental Health , Diabetes Research , German Institute Of Human Nutrition Dif , Nephrology Of The University Hospital , German Center , Helmholtz Center Munich , University Hospital , Paul Langerhans Institute Dresden Of Helmholtz Zentrum , Institute Of Diabetes Research , Carl Gustav Carus University Hospital , German Centers For Health Research , Clinical Investigation , Metabolic Disorders , Im Not Dead , Internal Medicine , German Centers , Research Center , German Institute , Human Nutrition , Metabolic Diseases ,

The interconnection of global pandemics -- Obesity, impaired metabolic health and COVID-19

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IMAGE: Obesity and cardiometabolic diseases do not only trigger a more severe course of COVID-19, the SARS-CoV-2 infection could promote the development of these conditions.
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Credit: Norbert Stefan
In a
Nature Reviews Endocrinology article authors from the German Center for Diabetes Research (DZD) highlight the interconnection of obesity and impaired metabolic health with the severity of COVID-19. First, they provide information about the independent relationships of obesity, disproportionate fat distribution and impaired metabolic health with the severity of COVID-19. Then they discuss mechanisms for a complicated course of COVID-19 and how this disease may impact on the global obesity and cardiometabolic pandemics. Finally, they provide recommendations for prevention and treatment in clinical practice and in the public health sector to combat these global pandemics. ....

Baden Wuberg , Andreas Birkenfeld , Norbert Stefan , Matthias Schulze , Department Of Internal Medicine , German Diabetes Center , German Research Center , Diabetes Research , Environmental Health , German Institute Of Human Nutrition Dif , German Center , Paul Langerhans Institute Dresden Of Helmholtz Zentrum , University Hospital , Institute Of Diabetes Research , Carl Gustav Carus University Hospital , German Centers For Health Research , Nature Reviews Endocrinology , Internal Medicine , German Centers , Research Center , German Institute , Human Nutrition , Metabolic Diseases , Paul Langerhans Institute Dresden , ஆண்ட்ரியாஸ் பிர்கன்பெல்ட் , நோர்பர்ட் ஸ்டீபன் ,