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Researchers Use Lasers And Molecular Tethers To Create Perfectly Patterned Platforms For Tissue Engineering

Researchers Use Lasers And Molecular Tethers To Create Perfectly Patterned Platforms For Tissue Engineering
Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own.
There are two major hurdles to overcome on the road to laboratory-grown organs and tissues. The first is to use a biologically compatible 3D scaffold in which cells can grow. The second is to decorate that scaffold with biochemical messages in the correct configuration to trigger the formation of the desired organ or tissue. ....

Cole Deforest , Ivan Batalov , Kelly Stevens , Uw Institute For Stem Cell , University Of Washington , Proceedings Of The National Academy Sciences , National Institutes Of Health , National Science Foundation , Sciences Institute , National Academy , Stem Cell , Space Needle , National Institutes , Gree Real , கோல் காடழிப்பு , கெல்லி ஸ்டீவன்ஸ் , ஊவ் நிறுவனம் க்கு தண்டு செல் , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தேசிய அறிவியல் அடித்தளம் , அறிவியல் நிறுவனம் , தேசிய கலைக்கழகம் , தண்டு செல் , இடம் ஊசி , தேசிய நிறுவனங்கள் , கிரே ரியல் ,

Researchers develop a technique to modify biological polymers with protein-based biochemical messages

Researchers develop a technique to modify biological polymers with protein-based biochemical messages
Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own.
There are two major hurdles to overcome on the road to laboratory-grown organs and tissues. The first is to use a biologically compatible 3D scaffold in which cells can grow. The second is to decorate that scaffold with biochemical messages in the correct configuration to trigger the formation of the desired organ or tissue. ....

Cole Deforest , Ivan Batalov , Kelly Stevens , Emily Henderson , Uw Institute For Stem Cell , University Of Washington , Proceedings Of The National Academy Sciences , Sciences Institute , National Academy , Stem Cell , Chemical Engineering , Space Needle , Tissue Engineering , Mammalian Cells , Notch Signaling , கோல் காடழிப்பு , கெல்லி ஸ்டீவன்ஸ் , எமிலி ஹென்டர்சன் , ஊவ் நிறுவனம் க்கு தண்டு செல் , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , அறிவியல் நிறுவனம் , தேசிய கலைக்கழகம் , தண்டு செல் , இரசாயன பொறியியல் , இடம் ஊசி , திசு பொறியியல் ,

Lasers & molecular tethers create perfectly patterned platforms for tissue engineering

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IMAGE: Top view of two collagen hydrogels that researchers decorated with immobilized mCherry proteins, which glow red under fluorescent light. The team scanned near-infrared lasers in the shapes of a monster.
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Credit: Batalov et al., PNAS, 2021
Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own.
There are two major hurdles to overcome on the road to laboratory-grown organs and tissues. The first is to use a biologically compatible 3D scaffold in which cells can grow. The second is to decorate that scaffold with biochemical messages in the correct configuration to trigger the formation of the desired organ or tissue. ....

Cole Deforest , Ivan Batalov , Kelly Stevens , Uw Institute For Stem Cell , University Of Washington , Proceedings Of The National Academy Sciences , National Institutes Of Health , National Science Foundation , Sciences Institute , National Academy , Stem Cell , Space Needle , National Institutes , Gree Real , Biomedical Environmental Chemical Engineering , Cell Biology , Molecular Biology , Medicine Health , கோல் காடழிப்பு , கெல்லி ஸ்டீவன்ஸ் , ஊவ் நிறுவனம் க்கு தண்டு செல் , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தேசிய அறிவியல் அடித்தளம் , அறிவியல் நிறுவனம் , தேசிய கலைக்கழகம் ,