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RCT: Sage extract offers working memory and cognitive performance benefits
A sage extract and essential oil combination can significantly improve cognitive performance, according to a new industry funded RCT.
The Lamiaceae family of plants includes psychoactive herbs such as rosemary, lemon-balm, peppermint and sage, which have been shown to express high levels of phenolic acids and polyphenols​.
Extracts from this family of plants often share common mechanisms of action relevant to the brain - such as inhibition of acetylcholinesterase and binding allosterically to gamma-Aminobutyric acid (GABAA), nicotinic and muscarinic receptors - attributable to their terpene content​.
The phenolic constituents have also demonstrated cognitive effects such as increases in brain-derived neurotrophic factor (BDNF), and antioxidant and anti-inflammatory activities in neurons. A recent trial by Kennedy. D. O., et al​ demonstrated the more robu ....

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