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서울성모병원, 혈액암 일종 다발골수종 세포치료제 임상 3상 돌입

서울성모병원 혈액병원은 10일 다발골수종 환자를 대상으로 '키메라 항원 수용체 T세포(CAR-T세포) 치료제'에 대한 임상시험 3상을 시작했으며 지난달 치료받은 환자를 퇴원시킨 후 경과를 관찰하고 있다고 밝혔다. 왼쪽부. ....

Soult Ukpyolsi , South Korea , Sarah Lee , Song Su Pak , Song Su Pak The Professor , Car T , தெற்கு கொரியா , சாரா லீ , கார் டி ,

Tmunity stops solid tumor CAR-T trial after 2 patients die

Jun 3, 2021 8:40am
The setback has led to the winding down of the CART-PSMA-TGFβRDN study. (Image by Dimitris Vetsikas from Pixabay)
Tmunity Therapeutics has stopped development of its lead CAR-T therapy after two patients died of a form of neurotoxicity. The news, details of which were first reported by Endpoints, has implications for the broader push to establish cell therapies as treatments for solid tumors.
Founded by Carl June, M.D., and Oz Azam, M.D., Tmunity is at the forefront of the push to expand use of CAR-T beyond hematological malignancies and into solid tumors. The University of Pennsylvania, which spawned Tmunity, took dual PSMA-specific, TGFβ-resistant CAR modified autologous T cells into an 18-subject phase 1 prostate cancer trial in 2017. Tmunity began a second, larger study late in 2019. ....

Oz Azam , University Of Pennsylvania , Tmunity Therapeutics , Carl June , University Of Pennsylvania , Carl June , Car T , Solid Tumor , Side Effects , ஆஸ் அஸாம் , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , கார்ல் ஜூன் , கார் டி ,