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New tool for watching and controlling neural activity

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A new molecular probe from Stanford University could help reveal how our brains think and remember. This tool, called Fast Light and Calcium-Regulated Expression or FLiCRE (pronounced flicker ), can be sent inside any cell to perform a variety of research tasks, including tagging, recording and controlling cellular functions.
This work gets at a central goal of neuroscience: How do you find the system of neurons that underlie a thought or cognitive process? Neuroscientists have been wanting this type of tool for a long time, said Alice Ting, professor of genetics in the Stanford School of Medicine and of biology in the School of Humanities and sciences, whose team co-led this work with the lab of Stanford psychiatrist and bioengineer, Karl Deisseroth. ....

Karl Deisseroth , Chan Zuckerberg Biohub , Paul Hoerbelt , Christina Kim , Stanford Bio , Robert Malenka , National Institute On Drug Abuse , Idun Berry Postdoctoral Fellowship Program , Wiegers Family Fund , Stanford School Of Medicine , Wu Tsai Neurosciences Institute , School Of Humanities , National Institute Of Mental Health , Maternal Child Health Research Institute , Nancy Pritzker Laboratory , Betsy Reeves Fund , Hl Snyder Medical Foundation , Sae Foundation , Fresenius Foundation , Stanford Cancer Institute , Defense Advanced Research Projects Agency , Gatsby Foundation , James Grosfeld Foundation , Behavioral Sciences , Stanford University , Fast Light ,

Tagging, recording and replaying neural activity

Neuroscientists have to choose between seeing the entire brain in low resolution or seeing a small piece of it in high resolution but a new technique known as FLARE could bring that dream one step closer to reality.
Whereas existing tagging techniques require hours to activate, the FLiCRE tagging process takes just minutes. The researchers also designed FLiCRE so that they can use standard genetic sequencing to find the cells in which FLiCRE activated. This allows them to study tens of thousands of cells at once, while other techniques tend to require the analysis of multiple microscopic images that each contain hundreds of cells. ....

Karl Deisseroth , Chan Zuckerberg Biohub , Paul Hoerbelt , Christina Kim , Stanford Bio , Robert Malenka , National Institute On Drug Abuse , Idun Berry Postdoctoral Fellowship Program , Wiegers Family Fund , Stanford School Of Medicine , Wu Tsai Neurosciences Institute , School Of Humanities , National Institute Of Mental Health , Maternal Child Health Research Institute , Nancy Pritzker Laboratory , Betsy Reeves Fund , Hl Snyder Medical Foundation , Sae Foundation , Fresenius Foundation , Stanford Cancer Institute , Defense Advanced Research Projects Agency , Gatsby Foundation , James Grosfeld Foundation , Behavioral Sciences , Stanford University , Fast Light ,