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Researchers develop mutant gene-targeted immunotherapy approach to fight cancers


Researchers develop mutant gene-targeted immunotherapy approach to fight cancers
A novel targeted immunotherapy approach developed by researchers at the Ludwig Center, the Lustgarten Laboratory, and Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center employs new antibodies against genetically altered proteins to target cancers.
The researchers targeted their immunotherapy approach to alterations in the common cancer-related p53 tumor suppressor gene, the RAS tumor-promoting oncogene or T-cell receptor genes. They also tested the therapy on cancer cells in the laboratory and in animal tumor models. Their findings are reported in three related studies published March 1 in
Science Immunology, ....

Emily Han , Emily Henderson , Bert Vogelstein , Suman Paul , Kenneth Kinzler , Katharine Wright , Alex Pearlman , Jacqueline Douglass , Sandra Gabelli , Johns Hopkins , Chung Hsiue , Bloomberg Kimmel Institute For Cancer Immunotherapy , Johns Hopkins Kimmel Cancer Center , Ludwig Center , Experimental Therapeutics For The Ludwig Center , Johns Hopkins University School Of Medicine , Howard Hughes Medical Institute , Lustgarten Laboratory , Kimmel Institute , Science Immunology , Science Translational , Johns Hopkins University School , Emily Han Chung Hsiue , Johns Hopkins Report , Senior Author , Associate Professor ,