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Researchers conduct first-in-man clinical trial for new stem cell technology

Institutes and centres under the SingHealth Duke-NUS Academic Medical Centre (AMC) are joining hands together with Singapore's first private cord blood bank, Cordlife Group Limited (Cordlife), to test a novel technology that expands the number of blood-forming stem cells from stored umbilical cord blood (UCB) in a first-in-man study in Singapore. ....

Chris Laing , William Hwang , Emily Henderson , Cordlife Group Limited , Cell Therapy Centre , Department Of Haematology , Department Of Haematology At Singapore , Development Jointcte , National Cancer Centre Singapore , Stem Cell Biology Programme , Academic Medical Centre , Centre For Technology , Blood Cancer Centre , Medical Centre , Professor William Hwang , Stem Cell Biology , Prof Hwang , Therapy Centre , Singapore General Hospital , Cancer Centre , Joint Centre , Professor Chris Laing , Senior Associate Dean , Executive Director , Clinical Trial , Medical School ,

First-in-man clinical trial in S'pore for stem cell technology by SingHealth Duke-NUS AMC, Cordlife


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IMAGE: Upon collection after the delivery of a baby, cord blood is processed to extract stem cells and to prepare it for long-term cryopreservation
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Credit: Cordlife Group Limited
SINGAPORE, 11 May 2021 - Institutes and centres under the SingHealth Duke-NUS Academic Medical Centre (AMC) are joining hands together with Singapore s first private cord blood bank, Cordlife Group Limited (Cordlife), to test a novel technology that expands the number of blood-forming stem cells from stored umbilical cord blood (UCB) in a first-in-man study in Singapore. This is the first time a home-grown UCB cell therapy is being tested on humans. The technology has the potential to increase treatment options for patients suffering from blood cancers or blood-related conditions. ....

Chris Laing , William Hwang , Cordlife Group Limited , Cell Therapy Centre , Department Of Haematology , Department Of Haematology At Singapore , Development Jointcte , National Cancer Centre Singapore , Stem Cell Biology Programme , Academic Medical Centre , Centre For Technology , Blood Cancer Centre , Medical Centre , Professor William Hwang , Stem Cell Biology , Prof Hwang , Therapy Centre , Singapore General Hospital , Cancer Centre , Joint Centre , Professor Chris Laing , Senior Associate Dean , Executive Director , Singapore Ministry , National Medical Research Council , கிறிஸ் முட்டையிடும் ,

Singapore and US scientists uncover how the Wntless protein carries Wnts in its signalling pathways


Preventing Wnt from hitching a ride may offer new avenue for novel treatments for cancer and fibrosis.
Wnt in complex with its transporter WLS. Wnt (green) modified by an attached lipid (red) is transported by the carrier protein Wntless (shades of light brown) from its site of synthesis to the plasma membrane. The attached lipid is buried deep in the Wntless structure.
David M. Virshup
SINGAPORE, 12 January 2021 – Researchers from Duke-NUS Medical School in Singapore and Columbia University in the US have solved how Wnt proteins, which play a fundamental role in cell proliferation and differentiation, hitch a ride to travel from their cellular factory to the cell surface. Drugs that interfere with Wnt transport, like the made-in-Singapore anti-cancer drug ETC-159, can be used to treat diseases with excess Wnt signalling, such as cancer and fibrosis. ....

Filippo Mancia , Lyu Jia , David Virshup , Senior Research Fellow At , Cellular Biophysics At Columbia University Medical Center , Agency For Science , Experimental Drug Development Centre , Stem Cell Biology Programme , Mancia Lab , Columbia University , Professor David Virshup , Cellular Biophysics , Columbia University Medical Center , Rie Nygaard , Senior Research Fellow , Stem Cell Biology , பிலிப்போ மான்சியா , யூ ஜியா , மூத்தவர் ஆராய்ச்சி சக இல் , செல்லுலார் உயிர் இயற்பியல் இல் கொலம்பியா பல்கலைக்கழகம் மருத்துவ மையம் , சோதனை மருந்து வளர்ச்சி மையம் , தண்டு செல் உயிரியல் ப்ரோக்ராம் , மான்சியா ஆய்வகம் , கொலம்பியா பல்கலைக்கழகம் , செல்லுலார் உயிர் இயற்பியல் , கொலம்பியா பல்கலைக்கழகம் மருத்துவ மையம் ,