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Knowing Risk Genes in Schizophrenia Helps Choose Proper Antipsychotic


Knowing Risk Genes in Schizophrenia Helps Choose Proper Antipsychotic
by Angela Mohan on 
February 26, 2021 at 12:01 PM
Current Pharmaceutical Design (Bentham Science Publishers) by Werner and Coveñas.
In schizophrenia, 260 risk genes have been discovered, and an association between single SNPs and the clinical efficacy of a specific antipsychotic drug has been established.
Among the risk genes in schizophrenia, the COMT, MAO A/B, GAD 67, DAOA, dysbindin-1 and neuregulin-1 genes are described, and their functions can be represented by an updated neural network model of the ventral tegmental area, hippocampus and prefrontal cortex.
The COMT and MAO A/B genes encode a decreased dopamine degradation. As a consequence, dopamine hyperactivity via D2 receptors occurs in the hippocampus and ventral tegemental area. The GAD 67 gene encodes a GABA dysfunction. Consequently, GABAergic neurons weakly inhibit D2 dopaminergic neurons in the hippoca ....

Mental Health , Schizophreniaweaver Syndromemental Health , Current Pharmaceutical Design , Bentham Science Publishers , May Increase , Weaver Syndromemental Health , Risk Genes , Single Nucleotide Polymorphisms , Snp S , New Targets , Antipsychotic Drugs , மன ஆரோக்கியம் , தற்போதைய மருந்து வடிவமைப்பு , பெந்தம் அறிவியல் வெளியீட்டாளர்கள் , இருக்கலாம் அதிகரி , ஆபத்து ஜீந்ஸ் , ஸ்ந்ப் கள் , புதியது இலக்குகள் ,

Study reveals information about risk genes in schizophrenia


Study reveals information about risk genes in schizophrenia
Dr. Felix-Martin Werner, working at the Euro Academy Pößneck in Germany and Prof. Rafael Coveñas, working at the Institute of Neurosciences of Castilla and León, Salamanca in Spain, have been working on neurological and psychiatric disease for over ten years.
In their most recent review, published in
Current Pharmaceutical Design (Bentham Science Publishers) Werner and Coveñas cover information about the risk genes in schizophrenia and explain the importance of examining their single nucleotide polymorphisms (SNP s). In schizophrenia, 260 risk genes have been discovered, and an association between single SNPs and the clinical efficacy of a specific antipsychotic drug has been established. ....

Castillay Leóp , Rafael Cove , Felix Martin Werner , Emily Henderson , Institute Of Neurosciences Castilla , Euro Academy , Current Pharmaceutical Design , Bentham Science Publishers , Single Nucleotide Polymorphisms , ரஃபேல் கோவ் , ஃபெலிக்ஸ் மார்டின் வெர்னர் , எமிலி ஹென்டர்சன் , நிறுவனம் ஆஃப் நரம்பியல் காஸ்டில்லா , யூரோ கலைக்கழகம் , தற்போதைய மருந்து வடிவமைப்பு , பெந்தம் அறிவியல் வெளியீட்டாளர்கள் ,

Risk genes in schizophrenia - their importance in choosing appropriate antipsychotic drug


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IMAGE: Risk genes in Schizophrenia and Examining the Single Nucleotide Polymorphisms of these Genes in order to choose an Appropriate Antipsychotic Treatment
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Credit: Dr. Felix-Martin Werner, Dr. Rafael Coveñas
Dr. Felix-Martin Werner, working at the Euro Academy Pößneck in Germany and Prof. Rafael Coveñas, working at the Institute of Neurosciences of Castilla and León, Salamanca in Spain, have been working on neurological and psychiatric disease for over ten years. In their most recent review, published in
Current Pharmaceutical Design (Bentham Science Publishers) Werner and Coveñas cover information about the risk genes in schizophrenia and explain the importance of examining their single nucleotide polymorphisms (SNP s). In schizophrenia, 260 risk genes have been discovered, and an association between single SNPs and the clinical efficacy of a specific antipsychotic drug has been established. Among the risk genes in schizop ....

Castillay Leóp , Rafael Cove , Felix Martin Werner , Institute Of Neurosciences Castilla , Euro Academy , Current Pharmaceutical Design , Bentham Science Publishers , ரஃபேல் கோவ் , ஃபெலிக்ஸ் மார்டின் வெர்னர் , நிறுவனம் ஆஃப் நரம்பியல் காஸ்டில்லா , யூரோ கலைக்கழகம் , தற்போதைய மருந்து வடிவமைப்பு , பெந்தம் அறிவியல் வெளியீட்டாளர்கள் ,