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Kanazawa University research: Understanding a nanomuscle


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KANAZAWA, Japan, July 14, 2021 /PRNewswire/  Researchers at Kanazawa University report in
Proceedings of the National Academy of Sciences how a protein molecular motor can chop off a piece of cell membrane. The constrict-and-cut mechanism resembles that of a ratchet motor, and is of importance in processes mediating the entry of particles into cells.
Cells in the human body constantly receive substances from the outside via a process called endocytosis. One important endocytosis pathway involves the formation of a protrusion within the cell membrane, pointing to the inside of the cell, triggered when a molecule needing to get in reaches the membrane. The protrusion wraps and closes around the molecule, after which it is cut off, leaving the wrapped molecule (a so-called vesicle) inside the cell. A key role in the cutting-off mechanism is played by dynamin, a protein that can locally constrict cell membranes, and chop off bits. The precise c ....

Hagen Hofmann , Alexanders Mikhailov , Gabriel Rosenblum , Alexander Mikhailov , Jeffreyk Noel , Olegm Ganichkin , Oliver Daumke , Renee Vancraenenbroeck , Hiroe Yoneda , Public Affairs , Proceedings Of The National Academy Sciences , Nano Life Science Institute , Kanazawa University , Researchers At Kanazawa University , National Academy , Life Science Institute , பொது வாழ்க்கைத்தொழில்கள் , நானோ வாழ்க்கை அறிவியல் நிறுவனம் , கனசாவா பல்கலைக்கழகம் , ஆராய்ச்சியாளர்கள் இல் கனசாவா பல்கலைக்கழகம் , தேசிய கலைக்கழகம் , வாழ்க்கை அறிவியல் நிறுவனம் ,