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Beware of fellow bacteria bearing gifts: Skoltech research presents new potential antimicrobial agen

Beware of fellow bacteria bearing gifts: Skoltech research presents new potential antimicrobial agen
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Konstantin Severinov , Svetlana Dubiley , Dmitrii Travin , Massachusetts Institute Of Technology , Institute Of Gene Biology , Biomedical Teaching Laboratory , Waksman Institute For Microbiology , Professor Konstantin Severinov , Gene Biology , Waksman Institute , Massachusetts Institute , மாசசூசெட்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , நிறுவனம் ஆஃப் கீந் உயிரியல் , கீந் உயிரியல் , மாசசூசெட்ஸ் நிறுவனம் ,

'Bespoke' analysis of DNA packaging sheds light on intricacies of the fundamental process

E-Mail
Researchers from Skoltech and their colleagues have optimized data analysis for a common method of studying the 3D structure of DNA in single cells of a Drosophila fly. The new approach allows the scientists to peek with greater confidence into individual cells to study the unique ways DNA is packaged there and get closer to understanding this crucial process s underlying mechanisms. The paper was published in the journal
Nature Communications.
The reason a roughly two-meter-long strand of DNA fits into the tiny nucleus of a human cell is that chromatin, a complex of DNA and proteins, packages it into compact but very complex structures. To study the way DNA is packaged, researchers worldwide have developed so-called chromosome conformation capture (3C) techniques, the most efficient of which is called Hi-C. Hi-C essentially catalogs all interacting fragments of a DNA strand via high-throughput sequencing. ....

Sankt Peterburg , Aleksandra Galitsyna , Mikhail Gelfand , Ekaterina Khrameeva , Nature Communications , Institute Of Gene Biology , Russian Interdisciplinary Scientific Center , French National Centre For Scientific Research , Skoltech Center , Life Sciences Ekaterina Khrameeva , Lomonosov Moscow State University , Biomedical Research , Topologically Associating Domains , Skoltech Vice President , Gene Biology , Russian Academy , French National Centre , Scientific Research , Biomedical Environmental Chemical Engineering , மிகைல் கெல்பண்ட் , இயற்கை தகவல்தொடர்புகள் , நிறுவனம் ஆஃப் கீந் உயிரியல் , ரஷ்ய இடைநிலை அறிவியல் மையம் , பிரஞ்சு தேசிய மையம் க்கு அறிவியல் ஆராய்ச்சி , உயிர் மருத்துவ ஆராய்ச்சி , கீந் உயிரியல் ,

'Bespoke' Analysis Of DNA Packaging Sheds Light On The Intricacies Of The Fundamental Process

Wednesday, 13 January 2021, 7:22 am
Researchers from Skoltech and their colleagues have
optimized data analysis for a common method of studying the
3D structure of DNA in single cells of a
Drosophila
fly. The new approach allows the scientists to peek with
greater confidence into individual cells to study the unique
ways DNA is packaged there and get closer to understanding
this crucial process s underlying mechanisms. The paper was
published
in the journal
Nature Communications.
The
reason a roughly two-meter-long strand of DNA fits into the
tiny nucleus of a human cell is that chromatin, a complex of
DNA and proteins, packages it into compact but very complex ....

Sankt Peterburg , Aleksandra Galitsyna , Mikhail Gelfand , Ekaterina Khrameeva , Nature Communications , Institute Of Gene Biology , Russian Interdisciplinary Scientific Center , French National Centre For Scientific Research , Skoltech Center , Citizen Community , Foundation For Public Interest Journalism , Life Sciences Ekaterina Khrameeva , Lomonosov Moscow State University , Biomedical Research , Topologically Associating Domains , Skoltech Vice President , Gene Biology , Russian Academy , French National Centre , Scientific Research , Scoop Citizen Community , In Depth Engaged Journalism , Scoop Foundation , Public Interest Journalism , World Europe , World News ,

'Fun size' Cas9 nucleases hold promise for easier genome editing

E-Mail
Researchers from Skoltech and their colleagues from Russia and the US have described two new, compact Cas9 nucleases, the cutting components of CRISPR-Cas systems, that will potentially expand the Cas9 toolbox for genome editing. One of the two nucleases has been shown to work in human cells and thus can have biomedical applications. The paper was published in the journal
Nucleic Acids Research.
CRISPR-Cas, the genome editing technology borrowed from bacteria, relies on Cas nucleases; these enzymes, when guided by CRISPR RNAs, can degrade target genetic sequences they are the blades in the Nobel Prize-worthy genetic scissors. In research applications, the most popular Cas9 nuclease is the Streptococcus pyogenes one, Type II-A SpCas9. It is efficient and relatively simple, as one large protein both binds to crRNA and cleaves DNA; it also requires a short PAM a string of nucleotides bookending the target site that the enzyme uses to locate and read it. ....

Saint Petersburg , Sankt Peterburg , Kurskaya Oblast , Aleksandra Vasileva , Skoltech Severinov , Russian Academy Of Sciences , National Center , Institute Of Gene Biology , National Institutes Of Health , Nucleic Acids Research , Saint Petersburg State University , National Library Of Medicine , Petersburg Polytechnic University , Nucleic Acids , Nobel Prize Worthy , Iana Fedorova , Skoltech Phd , Gene Biology , Russian Academy , Molecular Genetics , National Research Center , Biotechnology Information , National Library , National Institutes , துறவி பீட்டர்ஸ்பர்க் , ரஷ்ய கலைக்கழகம் ஆஃப் அறிவியல் ,