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Beta blockers can repair malformed blood vessels in the brain


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IMAGE: Propranolol treatment contributes to reduced number and size of cerebral cavernous malformations. Panel A shows a brain section of vehicle treated mouse. The lesions are outlined in green.
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Credit: Joppe Oldenburg
Peer review/Experimental study/Animals
Propranolol, a drug that is efficacious against infantile haemangiomas ( strawberry naevi , resembling birthmarks), can also be used to treat cerebral cavernous malformations, a condition characterised by misshapen blood vessels in the brain and elsewhere. This has been shown by researchers at Uppsala University in a new study published in the scientific journal
Stroke.
Up to now, there s been no drug treatment for these patients, so our results may become hugely important for them, says Peetra Magnusson of the University s Department of Immunology, Genetics and Pathology, who headed the study. ....

Uppsala Lan , Peetra Magnusson , Mario Negri Institute Of Pharmacological Research , Uppsala University , Uppsala University Department Of Immunology , Swedish University Of Agricultural Sciences , University Department Of Immunology , Institute Of Molecular Oncology , Propranolol Reduces The Development Of Lesions , Swedish University , Agricultural Sciences , Molecular Oncology , Mario Negri Institute , Professor Elisabetta Dejana , Propranolol Reduces , Rescues Barrier Function , Cerebral Cavernous Malformations , Medicine Health , Internal Medicine , Pharmaceutical Science , மரியோ நெக்ரி நிறுவனம் ஆஃப் மருந்தியல் ஆராய்ச்சி , பல்கலைக்கழகம் துறை ஆஃப் நோயெதிர்ப்பு , நிறுவனம் ஆஃப் மூலக்கூறு புற்றுநோயியல் , ஸ்விட்ச் பல்கலைக்கழகம் , மூலக்கூறு புற்றுநோயியல் , மரியோ நெக்ரி நிறுவனம் ,

Study: Beta blockers can repair malformed blood vessels in the brain