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SARS-CoV-2 spike S1 subunit induces hypercoagulability


SARS-CoV-2 spike S1 subunit induces hypercoagulability
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), is characterized by a range of clinical presentations. The vascular complications of the condition include a range of various coagulopathies that cause bleeding and thrombocytopenia or a hypercoagulable state. A new preprint research paper posted to the
medRxiv server describes the role of a fibrinogen-related protein in inducing these clinical features of COVID-19.
Cytokine dysregulation
Earlier research has shown a change in circulating cytokines involved in the inflammatory and coagulation pathways, indicating dysregulation of these biomarkers and the endothelium. These include fibrin(ogen), D-dimer, P-selectin and von Willebrand Factor (VWF), C-reactive protein (CRP), and other cytokines that bind to endothelial receptors. ....

Liji Thomas , Willebrand Factor , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , C Reactive Protein , D Dimer , Mass Spectrometry , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , கொரோனா வைரஸ் , நிறை ஸ்பெக்ட்ரோமெட்ரி , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

'Organs-on-a-chip' sheds light on gut microbiome's role in Parkinson's disease


Researchers have developed an organs-on-a-chip system that models the interactions between the brain, gut microbiome, liver, and colon in patients with Parkinson’s disease.
The system allows the research team to more fully understand the gut-brain axis’ role in neurological diseases, better replicating the complex interactions that murine mice models struggle to do.
The team from Massachusetts Institute of Technology (MIT) found that short-chain fatty acids (SCFAs) produced by gut microbes are transported to the brain, where they have different effects on healthy and diseased brain cells.
“While short-chain fatty acids are largely beneficial to human health, we observed that under certain conditions they can further exacerbate certain brain pathologies, such as protein misfolding and neuronal death, related to Parkinson’s disease,” ​says Martin Trapecar, an MIT postdoc and the lead author of the study. ....

Martin Trapecar , Linda Griffith , Massachusetts Institute Of Technology , School Of Engineering Professor Teaching Innovation , Massachusetts Institute , Engineering Professor , Teaching Innovation , Science Advances , Gut Microbiome , Parkinson 039s Disease , லிண்டா கிரிஃபித் , மாசசூசெட்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , பள்ளி ஆஃப் பொறியியல் ப்ரொஃபெஸர் கற்பித்தல் கண்டுபிடிப்பு , மாசசூசெட்ஸ் நிறுவனம் , பொறியியல் ப்ரொஃபெஸர் , கற்பித்தல் கண்டுபிடிப்பு ,

The global microfluidic devices market is projected to reach US$ 22.65 Billion by 2026

The global microfluidic devices market is projected to reach US$ 22.65 Billion by 2026
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Global Microfluidic Devices Market , Microfluidic Devices , Company Profiles , Device Type , Microfluidic Devices Market , Market Share , Medical Devices , நிறுவனம் ப்ரொஃபைல்ஸ் , சாதனம் வகை , சந்தை பகிர் , மருத்துவ சாதனங்கள் ,