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February 19, 2021
In the same way that Lego pieces can be arranged in new ways to build a variety of structures, genetic elements can be mixed and matched to create new genes, according to new research.
A long-proposed mechanism for creating genes, called exon shuffling, works by shuffling functional blocks of DNA sequences into new genes that express proteins.
A study, “Recurrent Evolution of Vertebrate Transcription Factors by Transposase Capture,” published Feb. 19 in Science, investigates how genetic elements called transposons, or “jumping genes,” are added into the mix during evolution to assemble new genes through exon shuffling.
Transposons, first discovered in the 1940s by Cornell alum and Nobel Prize-winner Barbara McClintock ’23, M.A. ’25, Ph.D. ’27, are abundant components of genomes – they make up half of human DNA – and have the ability to hop and replicate selfishly in the genome. Some transposons contain their own genes that code f ....

Rachel Cosby , Alan Zhong , Nathaniel Garry , Ruiling Zhang , Cedric Feschotte , Julius Judd , Barbara Mcclintock , Ellen Pritham , Department Of Molecular Biology , National Institutes Of Health , Life Sciences , College Of Agriculture , Vertebrate Transcription Factors , Transposase Capture , Nobel Prize Winner Barbara Mcclintock , National Institutes , Molecular Biology , ரேச்சல் கோசப்ய , ஆலன் ஜாங் , நத்யாநியல் ஆடை , ஜூலியஸ் தீர்ப்பு , பார்பரா ம்க்கிலிந்தோக்க் , துறை ஆஃப் மூலக்கூறு உயிரியல் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , வாழ்க்கை அறிவியல் , முதுகெலும்பு படியெடுத்தல் காரணிகள் ,