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The weak spot of colon cancer stem cells

The weak spot of colon cancer stem cells
Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body.
Since colonoscopies were introduced in Germany for early cancer detection, the number of diagnoses of advanced cancer every year has decreased, as precancerous lesions can now be detected and immediately removed as part of the examination. As a result, the death rate from colon cancer has also gone down - by 26 percent in women and 21 percent in men. Nevertheless, it remains the fourth deadliest cancer in the Western world - just behind lung, prostate and breast cancer. This is because the slow-growing tumors only become noticeable in the advanced stages of the disease and are therefore often diagnosed too late. Survival rate for advanced colorectal cancer is just five percent. ....

Comunidad Autonoma De Cataluna , Johanna Grinat , Walter Birchmeier , Eduard Batlle , Julian Heuberger , Emily Henderson , University Hospital , Nature Communications , Department Of Charit , Transduction In Development , Cancer Lab , Division Of Hepatology , Lead Author , Doctoral Student , Signal Transduction , Professor Walter Birchmeier , Professor Eduard Batlle , Medical Department , காமுனிடட தன்னாட்சி டி கடலுள் , வால்டர் பிர்ச்மியர் , ஜூலியன் ெஉபேற்கேற் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் மருத்துவமனை , இயற்கை தகவல்தொடர்புகள் , துறை ஆஃப் அறம் , கடத்தல் இல் வளர்ச்சி ,

Epigenetic Regulator Mll1 Linked to Most Severe Forms of Colon Cancer

Epigenetic Regulator Mll1 Linked to Most Severe Forms of Colon Cancer
Expanding cancer stem cells (green) in a colon tumor with an oncogenic activated Wnt/beta-catenin signaling pathway (red).[Birchmer Lab, MDC]
December 22, 2020
Expanding cancer stem cells (green) in a colon tumor with an oncogenic activated Wnt/beta-catenin signaling pathway (red). [Birchmer Lab, MDC]
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Together with bioinformaticians at the Institute for Research in Biomedicine (IRB) in Barcelona, a group at the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association in Germany used clinical data to show that colon cancer patients whose tumors have a large amount of this protein have a worse prognosis than patients with tumors that contain little Mll1. Their study (“The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness”) appears in ....

Comunidad Autonoma De Cataluna , Max Delbr , Walter Birchmeier , Julian Heuberger , University Hospital , Nature Communications , Helmholtz Association , Institute For Research , Molecular Medicine , காமுனிடட தன்னாட்சி டி கடலுள் , வால்டர் பிர்ச்மியர் , ஜூலியன் ெஉபேற்கேற் , பல்கலைக்கழகம் மருத்துவமனை , இயற்கை தகவல்தொடர்புகள் , நிறுவனம் க்கு ஆராய்ச்சி , மூலக்கூறு மருந்து ,

The Achilles' heel of cancer stem cells

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IMAGE: Expanding cancer stem cells (green) in a colon tumor with an oncogenic activated Wnt/beta-catenin signaling pathway (red).
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Credit: Birchmer Lab, MDC
Since colonoscopies were introduced in Germany for early cancer detection, the number of diagnoses of advanced cancer every year has decreased, as precancerous lesions can now be detected and immediately removed as part of the examination. As a result, the death rate from colon cancer has also gone down - by 26 percent in women and 21 percent in men. Nevertheless, it remains the fourth deadliest cancer in the Western world - just behind lung, prostate and breast cancer. This is because the slow-growing tumors only become noticeable in the advanced stages of the disease and are therefore often diagnosed too late. Survival rate for advanced colorectal cancer is just five percent. ....

Comunidad Autonoma De Cataluna , Johanna Grinat , Walter Birchmeier , Eduard Batlle , Julian Heuberger , University Hospital , Department Of Charit , Transduction In Development , Cancer Lab , Division Of Hepatology , Signal Transduction , Professor Walter Birchmeier , Professor Eduard Batlle , Medical Department , காமுனிடட தன்னாட்சி டி கடலுள் , வால்டர் பிர்ச்மியர் , ஜூலியன் ெஉபேற்கேற் , பல்கலைக்கழகம் மருத்துவமனை , துறை ஆஃப் அறம் , கடத்தல் இல் வளர்ச்சி , புற்றுநோய் ஆய்வகம் , பிரிவு ஆஃப் ஹெபடாலஜி , சமிக்ஞை கடத்தல் , ப்ரொஃபெஸர் வால்டர் பிர்ச்மியர் , மருத்துவ துறை ,