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Reason for Neonatal Strokes Identified!

Important cause of neonatal strokes occurring in the womb or just after birth has been discovered by scientists, which further paves the way for new treatments.

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Melbourne research team recognised with Clunies Ross Award

A team of researchers from WEHI and Monash University has received the 2021 Clunies Ross Knowledge Commercialisation Award from the Australian Academy of...

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New cellular atlas maps out healthy and cancerous breast tissue

Date Time
New cellular atlas maps out healthy and cancerous breast tissue
WEHI researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells.
The diversity of cells in the human breast has been
documented in a new ‘RNA atlas’.
The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including tissue carrying a faulty BRCA1 gene. This enabled the researchers to create an ‘RNA atlas’ that details the different cells found in these tissues.

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Natural immunity to malaria provides clues to potential therapies

Date Time
Natural immunity to malaria provides clues to potential therapies
WEHI researchers have identified how natural human antibodies can block malaria parasites from entering red blood cells, potentially indicating how new protective therapies could be developed against this globally significant disease.
Dr Melanie Dietrich, Li Jin Chan and Associate Professor
Wai-Hong Tham
The research provides greater insight into how antibodies block the entry of Plasmodium vivax malaria parasites into young red blood cells called reticulocytes. It builds on an earlier discovery that the P. vivax latches onto the transferrin receptor 1 (TfR1) to enter cells.
The research, led by Associate Professor Wai-Hong Tham and PhD student Li-Jin Chan from WEHI, alongside Professor Christopher King from Case Western University, US, was published in Nature Communications.

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Nanobodies inhibit SARS-CoV-2 infection

Date Time
Nanobodies inhibit SARS-CoV-2 infection
Australian researchers have identified neutralising nanobodies that block the SARS-CoV-2 virus from entering cells in preclinical models.
The discovery paves the way for further investigations into nanobody-based treatments for COVID-19.
Visualisation of SARS-CoV-2 virus with nanobodies (purple)
attaching to the virus ‘spike’ protein.
Image: Dr Drew Berry in collaboration with
Associate Professor Wai-Hong Tham
Published in PNAS, the research is part of a consortium-led effort, bringing together the expertise of Australian academic leaders in infectious diseases and antibody therapeutics at WEHI, the Doherty Institute and the Kirby Institute.
At a glance
Researchers have identified nanobodies that effectively blocked the SARS-CoV-2 virus from entering cells in pre-clinical models of COVID-19 infection.

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Researchers unveil new time machine technique to measure cells

Date Time
Researchers unveil new time machine technique to measure cells
Using a new single-cell technique, WEHI researchers have uncovered a way to understand the programming behind how stem cells make particular cell types.
L-R: Dr Shalin Naik, Mr Luyi Tian, Dr Tom Weber
and Ms Sara Tomei
The research uncovered 30 new genes that program stem cells to make the dendritic cells that kick-start the immune response.
By uncovering this process, the researchers hope they will be able to find new immunotherapy treatments for cancer, and plan to expand this technique in other areas such as discovering new drug targets in tumour initiation.

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Unravelling the mysteries of long COVID

Unravelling the mysteries of long COVID
updated 4
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ABC News: Daniel Fermer)
Three previously healthy people in their 30s are still dealing with symptoms months after being infected with COVID-19. As Australia rolls out its vaccination program, sufferers are calling for more recognition of this emerging condition.
"It's no life," says Sarah Hughes.
"Being sick and having pain every day at the age of 34, when this should be the prime of my life, is just very hard to deal with. And I think that's probably what causes me the most depression out of all of this."
It has been eight months since Sarah's role as a senior nurse in aged care brought her into the thick of Melbourne's second wave of COVID-19.

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Microscopic behaviour of developing breast cells uncovered

An improved high-tech fluorescence microscopy technique is allowing researchers to film cells inside the breast as never seen before. Dr Caleb Dawson...

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Why do kids tend to have milder COVID?

A new Australian study, published overnight in Nature Communications, gives an insight into how kids' immune systems respond to infection with...

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QueersInScience founder and LGBT+ role model recognised

Dr Sarah Stephenson co-founded QueersInScience in
June 2018.
Dr Sarah Stephenson has been featured in the OUTstanding LGBT+ Future Leaders Role Model List 2020.
Sarah was recognised for her outstanding achievements in championing LGBTQIA+ people in STEMM (Science, Technology, Engineering, Math and Medicine).
Sarah is co-founding director of QueersInScience, an initiative to increase the visibility and representation of LGBTQIA+ people in STEMM. QueersInScience has been proudly hosted and supported by WEHI since 2018.
The OUTstanding LGBT+ Future Leaders Role Model List 2020 is an initiative of INvolve, a global network and consultancy championing diversity and inclusion in business.
Championing diversity and inclusion
Sarah co-founded QueersInScience in June 2018 and, under her stewardship, it has grown from a grassroots Victorian medical research precinct initiative to a national movement, with established chapters in all Australian states.

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