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Compound may prevent risk of form of arrhythmia from common medications | The Source

Multi-institutional team combined expertise to make discovery
May 17, 2021
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Dozens of commonly used drugs, including antibiotics, anti-nausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart’s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Institute For Data Science , Skandalaris Center , Institute Of Clinical , Entrepreneurial Acceleration Program , Office Of Technology Management , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office , Technology Management ,

Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs

Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. The team found that the compound, named C28, not only prevents or reverses the negative physiological effects on the action potential, ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Emily Henderson , Institute For Data Science , Skandalaris Center , Office Of Technology Management , Institute Of Clinical , Entrepreneurial Acceleration Program , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office ,

Compound may prevent risk of a form of arrhythmia from common medications

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IMAGE: Xiaoqin Zou, professor of physics, biochemistry, and a member of the Dalton Cardiovascular Research Center and Institute for Data Science and Informatics at the University of Missouri
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Credit: University of Missouri
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these med ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Institute For Data Science , Skandalaris Center , Institute Of Clinical , Entrepreneurial Acceleration Program , Office Of Technology Management , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office , Technology Management ,

Heme is not just for Impossible Burgers | The Source | Washington University in St. Louis

Variation in how animals and bacteria use heme reveals potential target for new antibiotics
The Impossible Whopper pictured at a Burger King restaurant in Columbus, Georgia. Burger King started offering this burger featuring a patty made with heme in August 2019. (Image: Shutterstock)
May 11, 2021
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It took an unlikely food innovation earth-friendly vegetarian patties, made to taste and “bleed” like the familiar meaty ones to make people aware of heme.
But heme is an essential part of proteins found in most life forms, from tiny bacteria to soy plants to the human body. Heme plays a crucial role in supplying cells with the energy needed to carry out chemical reactions. ....

Mollyc Sutherland , Deannal Mendez , Shalone Babbitt , Robert Kranz , Washington University , Washington University Office Of Technology Management , University Of Delaware , Washington University In St , Arts Sciences , Washington University Office , Impossible Foods , Business Insider , Impossible Burger , ராபர்ட் கிரான்ஸ் , வாஷிங்டன் பல்கலைக்கழகம் , வாஷிங்டன் பல்கலைக்கழகம் அலுவலகம் ஆஃப் தொழில்நுட்பம் மேலாண்மை , பல்கலைக்கழகம் ஆஃப் டெலாவேர் , வாஷிங்டன் பல்கலைக்கழகம் இல் ஸ்டம்ப் , கலைகள் அறிவியல் , வாஷிங்டன் பல்கலைக்கழகம் அலுவலகம் , சாத்தியமற்றது உணவுகள் , வணிக உள் , சாத்தியமற்றது பர்கர் ,

Heme is not just for Impossible Burgers

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IMAGE: New research from Washington University in St. Louis in the journal eLife shows how animals and bacteria differ in the enzyme they use to attach heme to the cytochrome. Spotting.
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Credit: (Courtesy of Robert Kranz)
It took an unlikely food innovation earth-friendly vegetarian patties, made to taste and bleed like the familiar meaty ones to make people aware of heme.
But heme is an essential part of proteins found in most life forms, from tiny bacteria to soy plants to the human body. Heme plays a crucial role in supplying cells with the energy needed to carry out chemical reactions. ....

Mollyc Sutherland , Deannal Mendez , Shalone Babbitt , Robert Kranz , Washington University , Washington University Office Of Technology Management , University Of Delaware , Washington University In St , Arts Sciences , Washington University Office , Impossible Foods , Business Insider , Impossible Burger , ராபர்ட் கிரான்ஸ் , வாஷிங்டன் பல்கலைக்கழகம் , வாஷிங்டன் பல்கலைக்கழகம் அலுவலகம் ஆஃப் தொழில்நுட்பம் மேலாண்மை , பல்கலைக்கழகம் ஆஃப் டெலாவேர் , வாஷிங்டன் பல்கலைக்கழகம் இல் ஸ்டம்ப் , கலைகள் அறிவியல் , வாஷிங்டன் பல்கலைக்கழகம் அலுவலகம் , சாத்தியமற்றது உணவுகள் , வணிக உள் , சாத்தியமற்றது பர்கர் ,