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Combo Tx for RA Raises Fracture Risk


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Patients with rheumatoid arthritis (RA) who were treated with oral glucocorticoids and proton pump inhibitors (PPIs) were at increased risk for osteoporotic fracture, a large cohort study found.
Patients who were concomitant users of glucocorticoids and PPIs had a 1.6-fold increased risk of osteoporotic fracture (adjusted HR 1.60, 95% CI 1.35-1.89), reported Frank de Vries, PharmD, PhD, of Utrecht University in the Netherlands, and colleagues.
In contrast, for those who used either oral glucocorticoids or PPIs alone, the risk was only 1.2-fold higher. For glucocorticoid use alone, the adjusted hazard ratio was 1.23 (95% CI 1.03-1.47), while for PPI use the hazard ratio was 1.22 (95% CI 1.05-1.42), which were statistically lower than for concomitant use of the two, according to the team s study online in ....

Utrecht University , Uk Clinical Practice Research Datalink , Frank De Vries , Practice Research Datalink , Fracture Of Bone , Rheumatoid Arthritis , அட்ரெக்ட் பல்கலைக்கழகம் , வெளிப்படையான டி வ்ரீஸ் , எலும்பு முறிவு ஆஃப் எலும்பு , முடக்கு கீல்வாதம் ,

Obits | The Mitchell Republic


Clara Noteboom
Corsica - Clara Noteboom, 100, died at Good Samaritan Society in Corsica on Monday, December 14, 2020. Celebration of life will be held at Grace Reformed Church in Corsica on Tuesday, December 29, 2020 at 10:30 AM. The family would appreciate all that attend wear masks. Arrangements by Koehn Bros. Funeral Home.
Clara Noteboom (De Vries) was born April 7, 1920, in Douglas County, SD to Gerrit H. and Allie (Menning) DeVries. She attended country school near Corsica. She married Andrew (Bud) Noteboom on June 20, 1939 and they shared 64 beautiful years together. To this union two daughters were born: Shirley and Nancy.
Clara was a lifelong member of Grace Reformed Church, where she was active in Ladies’ Missionary Society, and taught Bible school and Sunday school. She was a 25 year member of the Corsica Extension Club and Friendship Club. In honor of her 100th birthday, an Executive Proclamation from the State of South Dakota named April 7, 2020 as C ....

Melanie Kroese , Clara Noteboom , Irene Bosma , Van Peursem , Allie Menning Devries , Ollie Doorn , Sherman De Vries , Fannie Van Ekeren , David Davidson , Clarissa Kroese , Michael Stegmann , Bob Kroese , Good Samaritan Society In Corsica On , Grace Reformed Church , Good Samaritan Century Club , Corsica Extension Club , Ladie Missionary Society , Friendship Club , Good Samaritan Society , Douglas County , Executive Proclamation , South Dakota , Clara Noteboom Day , Good Samaritan Century , Good Samaritan Home , Dean Van Peursem ,