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A Child Rescue Ireland Alert has been issued in the search for 14-year-old Svetlana Murphy.
Gardaí say they have serious concerns there is an immediate risk to her health or welfare.
Gardaí says she is in the company of 18-year-old Nojus Maculevicius, and are travelling in a Hyundai Veloster car, with registration number 132-D-13518.
They were sighted in Newry on Monday at around 7pm, while the car was seen in the Belfast area at around 5.35pm yesterday evening.
Svetlana was last seen at her home on Coast Road in Blackrock in Louth and is described as 5'1", of slim build, with brown hair and brown eyes.