Researchers have demonstrated that it is possible to use the CRISPR gene-editing tool to stop SARS-CoV-2, the virus responsible for COVID-19, from replicating in infected human cells. The demonstration was done in culture cells in the lab so it is not a forthcoming treatment yet, but this approach could be revolutionary in the medium and long term.
As reported in Nature Communications, the team used the enzyme CRISPR-Cas13b to bind itself to the part of the virus’ genetic code – its RNA – used for replication. The enzyme degrades this bit of information leaving the virus unable to replicate.
“The flexibility of CRISPR-Cas13 – which only needs the viral sequence – means we can look to rapidly design antivirals for COVID-19 and any new emerging viruses,” senior author Professor Sharon Lewin, from the Peter Doherty Institute for Infection and Immunity in Australia, said in a statement.