Tricking the novel coronavirus with a fake “handshake”
Scientists develop peptides that could inactivate coronavirus
Fool the novel coronavirus once and it can’t cause infection of cells, new research suggests.
Scientists have developed protein fragments – called peptides – that fit snugly into a groove on the SARS-CoV-2 Spike protein that it would normally use to access a host cell. These peptides effectively trick the virus into “shaking hands” with a replica rather than with the actual protein on a cell’s surface that lets the virus in.
Previous research has determined that the novel coronavirus binds to a receptor protein on a target cell’s surface called ACE2. This receptor is located on certain types of human cells in the lung and nasal cavity, providing SARS-CoV-2 many access points to infect the body.