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March 16, 2021 Cancer cells can dodge chemotherapy by entering a state that bears similarity to certain kinds of senescence, a type of “active hibernation” that enables them to weather the stress induced by aggressive treatments aimed at destroying them, according to a new study by scientists at Weill Cornell Medicine. These findings have implications for developing new drug combinations that could block senescence and make chemotherapy more effective. In a study published Jan. 26 in Cancer Discovery, a journal of the American Association for Cancer Research, the investigators reported that this biologic process could help explain why cancers so often recur after treatment. The research was done in both organoids and mouse models made from patients’ samples of acute myeloid leukemia (AML) tumors. The findings were also verified by looking at samples from AML patients that were collected throughout the course of treatment and relapse. 

Fox chase cancer centerUnited statesCihangir duyAmerican association for cancer researchEdward meyer cancer centerWeill cornellCancer discoveryAmerican associationCancer researchGebroe family professorMedical oncologyநரி துரத்து புற்றுநோய் மையம்ஒன்றுபட்டது மாநிலங்களில்அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சிஎட்வர்ட் மேயர் புற்றுநோய் மையம்வெயில் கார்னெல்