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Aiming for single-dose home-grown COVID vaccine, Israel considers redoing clinical trials

Get email notification for articles from Ido Efrati Follow May. 4, 2021 6:18 PM Israel’s Institute for Biological Research is considering restarting its ongoing clinical trial from the beginning on the COVID-19 vaccine that it is developing. The step would be taken in the hope of developing a version that is effective with a single dose, Haaretz has learned. According to sources, it became apparent from the first and second phases of the clinical trials on the two-shot Israeli BriLife vaccine that it would be possible to forgo the second shot if patients were given a higher dose in a single injection.

Evidence of monoclonal antibodies effectively neutralizing SARS-CoV-2 variants

Evidence of monoclonal antibodies effectively neutralizing SARS-CoV-2 variants Evolving variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become a growing concern worldwide for their rapid transmission and ability to cause severe infection. New research led by Ronit Rosenfeld from the Israel Institute for Biological Research confirms evidence that specific monoclonal antibodies can bind to the receptor-binding domain of the B.1.1.7 and B.1.351 variants and effectively neutralize them. The study “The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against novel viral variants” is available as a preprint on the bioRxiv server, while the article undergoes peer review.

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