April 20, 2021
Patients in the SPRINT trial with the highest predicted risk of CVD at baseline derived the greatest benefit from intensive blood pressure lowering, but they also faced an increased likelihood of treatment-related adverse events.
Researchers say that since most of those events were mild and fleeting, particularly compared to the severity of the outcomes prevented, intensive therapy is worth the risk. Still, the findings, from a secondary analysis, have important implications for guidelines and practice.
“What we were hoping is that we would find a large number of people who derived a lot of benefit at very low risk of adverse events. And that is what we did not find,” senior author Andrew Moran, MD (Columbia University Irving Medical Center, New York, NY), told TCTMD.
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Though the SARS-CoV-2 virus primary target is said to be the respiratory system, the damage caused by the pathogen has not spared the other organs of the body. Now, a new study by researchers from Columbia University Irving Medical Center has reported that while the coronavirus does not infect the brain directly, it can still inflict considerable neurological damage.
According to the paper, which is the largest published report detailing COVID-19 brain autopsies involving over 40 patients, there were no signs of the virus in the brain cells of the afflicted. However, it is likely that the inflammation triggered by the virus in the brain s blood vessels or other parts of the body, can cause neurological changes in the brain.
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NEW YORK, NY (April 16, 2021) SARS-CoV-2, the virus that causes COVID-19, likely does not directly infect the brain but can still inflict significant neurological damage, according to a new study from neuropathologists, neurologists, and neuroradiologists at Columbia University Vagelos College of Physicians and Surgeons. There s been considerable debate about whether this virus infects the brain, but we were unable to find any signs of virus inside brain cells of more than 40 COVID-19 patients, says James E. Goldman, MD, PhD, professor of pathology & cell biology (in psychiatry), who led the study with Peter D. Canoll, MD, PhD, professor of pathology & cell biology, and Kiran T. Thakur, MD, the Winifred Mercer Pitkin Assistant Professor of Neurology.
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