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Credit: UAB BIRMINGHAM, Ala. - Six years ago, Michael Niederweis, Ph.D., described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. This toxin, tuberculosis necrotizing toxin, or TNT, became the founding member of a novel class of previously unrecognized toxins present in more than 600 bacterial and fungal species, as determined by protein sequence similarity. The toxin is released as M. tuberculosis bacteria survive and grow inside their human macrophage host, killing the macrophage and allowing the escape and spread of the bacteria. For 132 years, the lack of an identified toxin in M. tuberculosis had contrasted with nearly all other pathogenic bacteria whose toxins contribute to illness or death. M. tuberculosis infects 9 million people a year and kills more than 1 million.

United statesTerje doklandMichael niederweisNature communicationsDepartment of microbiologyUniversity of coloradoNational institutes of healthNational science foundationUniversity of alabama at birminghamUday takNational institutesEndowed professorshipஒன்றுபட்டது மாநிலங்களில்இயற்கை தகவல்தொடர்புகள்துறை ஆஃப் நுண்ணுயிரியல்பல்கலைக்கழகம் ஆஃப் கொலராடோ