Piperlongumine, a chemical compound found in the Indian long pepper plant, is known to kill cancerous cells in many tumor types, including brain tumors, according to Penn Medicine.
Now, an international team, including researchers from the University of Pennsylvaniaâs Perelman School of Medicine, has illuminated one way in which the piperlongumine works in animal models â and has confirmed its strong activity against glioblastoma, one of the least treatable types of brain cancer, the university announced in a press release.
The researchers, whose findings were published this month in ACS Central Science, showed in detail how piperlongumine binds to â and hinders the activity of â a protein called TRPV2, which is overexpressed in glioblastoma in a way that appears to drive cancer progression.
Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2 preprint server, researchers from the United States report that two iminosugar glucosidase inhibitors have the ability to suppress the replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in tissue culture – at concentrations of at least 100 times lower than required for cytotoxic effects.
As the coronavirus disease 2019 (COVID-19) pandemic marches on, new antiviral agents effective against SARS-CoV-2 are urgently needed, despite a growing availability of vaccines. Remdesivir is still the only drug fully licensed for the treatment of affected individuals, but its effectiveness is controversial.
Iminosugar glucosidase inhibitors have their role in various viral diseases (e.g., hepatitis B and Ebola), as they prevent the folding process of a range of viral N-linked glycoprotein. Furthermore, they are competitive inhibitors of the host endoplasmic reticular (ER) glucosida
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Significantly more patients with moderate-to-severe pemphigus sustained their complete remission with rituximab (Rituxan) than with mycophenolate mofetil (MMF), a randomized trial showed.
At 1 year, 40% of patients treated with rituximab had sustained complete remission after ≥16 weeks off prednisone, as compared with 10% of patients randomized to MMF. Rituximab treatment was associated with a significantly reduced need for glucocorticoids and with a dramatic reduction in the number of disease flares.
Quality-of-life scores improved more with rituximab, but MMF was associated with fewer serious adverse events (SAEs), reported Victoria Werth, MD, of the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues in the
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