December 13, 2020
The risk of becoming dependent on pain medication and sedatives after mastectomy and breast reconstruction surgery is more significant than doctors realized.
A study presented this week at the virtual meeting of the San Antonio Breast Cancer Symposium (SABCS) found that people who underwent mastectomy and breast reconstruction were at increased risk of developing dependence on pain and sedative medication.
The study showed that 13.1 percent of patients who were not prior opioid users became new persistent opioid users after surgery. Researchers found 6.6 percent of patients who were not prior sedative-hypnotic users became persistent users after surgery.
“It’s striking how many patients this is an issue for. It’s more than maybe we would have thought prior to doing the study,” said the lead author, Jacob Cogan, MD, a fellow in hematology-oncology at NewYork-Presbyterian Columbia University Irving Medical Center in New York City.
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December 11, 2020
A new analysis of the ISCHEMIA trial reveals its results are highly contingent on how myocardial infarction is defined, with investigators reporting a significant treatment difference between the invasive and conservative strategies when counting MIs using the more-sensitive biomarker: cardiac troponin (cTn).
When investigators analyzed events based on the secondary MI definition, which assessed PCI- and CABG-related infarctions using cTn levels as opposed to CK-MB, the conservative strategy of guideline-directed medical therapy was associated with a significantly lower risk of the study’s primary endpoint, a composite of cardiovascular death, MI, hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest, and a lower risk of cardiovascular death or MI, which was a secondary endpoint.