Aaron Gitler News Today

THE ELECTRIC STAIRS  Gary Marmorstein While Ed Ritter was on the land line with the manager of Mobility Lift and Elevator, he had to keep a finger in his other ear so he could hear above the noise of the giant vacuum cleaner upstairs. “I’m sorry, sir, could you repeat that?” “I asked, if I’m…

An email contained additional allegations about Marc Tessier-Lavigne’s Alzheimer’s research and the 2011 internal review that former colleagues allege uncovered falsification.

Ann Kennedy’s work shows how neuronal activity in the hypothalamus can fine-tune core animal behaviors.

Scientists discovered how a mislocated protein implicated in several neurodegenerative diseases affects another protein that’s needed for normal nerve cell functioning.

Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative disorders in which many cases are linked by mislocalization of the TDP-43 protein, where instead of being located in the nucleus of the cell where genes are activated, it forms aggregates outside the nucleus in multiple neurodegenerative diseases. Rare mutations in TDP-43 are known to cause ALS, but almost all cases of ALS show mislocalization of TDP-43.

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

Neuroscientists face a paradox. The field aims to understand the mysteries of the human mind, but studying the actual human brain cells and circuits that

Neuroscientists face a paradox. The field aims to understand the mysteries of the human mind, but studying the actual human brain cells and circuits that produce our mental lives—and how they go awry in neuropsychiatric disease—is incredibly challenging. After all, the brain is packed away carefully in our skulls, and people typically don’t part with samples of their brain

25 Apr 2021 In amyotrophic lateral sclerosis and frontotemporal dementia, loss of the RNA-binding protein TDP-43 from the nucleus creates a surge of mis-spliced mRNAs in neurons. So far, only one of these errant transcripts, stathmin-2, has been tied to disease pathology. Now, two preprints uploaded to bioRXiv on April 4 detail another—UNC13A. Variants in this gene increase risk for ALS/FTD. Neurons lacking nuclear TDP-43 mis-splice UNC13A, make less of the protein. UNC13A risk variants incor...