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A new study reports the level of ACE2 and furin, two enzymes that are intimately linked to infection with SARS-CoV-2, the causative agent of COVID-19.

Credits: Photo courtesy of Caltech. Previous image Next image Last month, the world welcomed the rollout of vaccines that may finally curb the Covid-19 pandemic. Pamela Björkman , the David Baltimore Professor of Biology and Bioengineering at Caltech, wants to understand how antibodies like the ones elicited by these vaccines target the SARS-CoV-2 virus that causes Covid-19. She hopes this understanding will guide treatment strategies and help design vaccines ...

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19 Researchers in China have conducted a study showing that a carbohydrate found in the seaweed Ecklonia kurome blocks the activity of an enzyme that is essential for the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). The seaweed – also called “Kun Bu” in China – has long been used as a medicinal plant in ...

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines As the coronavirus disease (COVID-19) pandemic continues to rage across the globe, many countries have rolled out vaccines. Populations to be vaccinated first are healthcare workers, front-liners, and high-risk individuals. The majority of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in use or advanced clinical development are based on the viral spike protein (S) as their immunogen. Since the star...

Which SARS-CoV-2 mutations can potentially evade antibody recognition? To date, the coronavirus disease 2019 (COVID-19) pandemic has spread to 191 countries and infected more than 95.62 million people. Of these, more than 2 million people have lost their lives. The United States remains the nation with the highest number of cases, reaching 24 million, while India and Brazil follow, with over 10.58 million and 8.51 million cases, respectively. New strains of the virus have begun to emerge with i...

A recent study by US researchers shows how the 501Y.V2 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterized by several mutations, is able to escape neutralization by present first-wave anti-SARS-CoV-2 antibodies and potentially re-infect COVID-19 convalescent individuals.

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans? The potentially deadly coronavirus disease 2019 (COVID-19) that has swept the world over the last 12 months has not affected animals with corresponding severity. In order to understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new prepr...

There have been significant efforts worldwide to combat COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One prominent strategy has been to develop vaccines against the virus. Numerous vaccine candidates are under development, and a handful have now been approved for use by several countries.

A new potential therapy for COVID-19 developed by researchers at Rush University Medical Center has shown success in preventing the disease's symptoms in mice.

White-tailed deer susceptible to SARS-CoV-2 infection, study finds A team of scientists from the United States has recently demonstrated that white-tailed deer are highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Moreover, the infected animals are capable of transmitting the virus to their non-infected counterparts via indirect contact. The study is currently available on the Background Although there is uncertainty about the exact origin of SARS-Co...